Crossbreeding can produce very interesting hybrids; however, I do not recommend doing it with poison arrow frogs. The problem with crossbreeding is that it contaminates the blood line that is available in the pet trade. Crossbred frogs can become sterile, limiting the number of frogs that are capable of reproducing. If the frogs do not become sterile, then they can be bred with pure-blood frogs, further contaminating bloodlines. My best recommendation is not to house species such as auratus, azureus, leucomelas, and tinctorius in the same enclosure. These species are too closely related.